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The two sisters became known as "The Black Widows of Liverpool".

In the state of Washington, Linda Burfield Hazzard, a doctor and a delusional "fasting specialist", believed she could "heal" her patients through exhausting diets and starvation.

Hazzard's practice of starvation resulted in the death of a visiting English heiress in 1911 and many others.

In Cordele, Georgia, greed led Janie Lou Gibbs, a church going mother and grandmother who once ran a day-care center, to poison her three sons, a grandson, and her husband in the 1960s for the sole purpose of collecting life insurance.

During the 1880s in Liverpool, England, sisters Catherine Flannigan & Margaret Higgins worked together to poison their own family members in an attempt to claim insurance payouts.

Renczi poisoned her husbands, lovers and one son with arsenic before placing their bodies in zinc-lined coffins in her wine cellar.

In New Orleans during the early 19th century, French socialite Delphine La Laurie was believed to be a cruel sadist who beat, tortured, and performed medical experiments on slaves in the basement of her mansion.

Valerie Parashumti and Jessica Stasinowsky – On December 18, 2006, in Perth, Australia, the lesbian couple drugged, bludgeoned, and strangled their 16-year-old flatmate Stacey Mitchell to death, after only knowing Stacey for 3 days.

Both women pleaded guilty and were sentenced to 24 years in prison. Petersburg, Florida, Dudley (a registered nurse suffering from Münchausen syndrome by proxy) murders twelve nursing home residents by overdosing them with insulin injections.

Each of the three original episodes covered the cases of various groups of women who were united by the central theme of the episode.

These three episodes of the show were narrated by Marsha Crenshaw.

After a three-year hiatus, the show resumed production in 2008 and began airing on the Investigation Discovery channel as a regularly scheduled series.

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